Abstract
AbstractUnintended pregnancy is a global issue with serious ramifications for women, their families, and society, including abortion, infertility, and maternal death. Although existing contraceptive strategies have been widely used in people's lives, there have not been satisfactory feedbacks due to low contraceptive efficacy and related side effects (e.g., decreased sexuality, menstrual cycle disorder, and even lifelong infertility). In recent years, biomaterials-based long-acting reversible contraception has received increasing attention from the viewpoint of fundamental research and practical applications mainly owing to improved delivery routes and controlled drug delivery. This review summarizes recent progress in advanced biomaterials for long-acting reversible contraception via various delivery routes, including subcutaneous implant, transdermal patch, oral administration, vaginal ring, intrauterine device, fallopian tube occlusion, vas deferens contraception, and Intravenous administration. In addition, biomaterials, especially nanomaterials, still need to be improved and prospects for the future in contraception are mentioned.
Graphical Abstract
Funder
National Natural Science Foundation of China
Natural Science Foundation of Shandong Province
Innovation and technology program for the excellent youth scholars of higher education of Shandong province
Traditional Chinese Medicine Science and Technology Project of Shandong province
Publisher
Springer Science and Business Media LLC
Subject
Pharmaceutical Science,Applied Microbiology and Biotechnology,Biomedical Engineering,Molecular Medicine,Medicine (miscellaneous),Bioengineering
Reference179 articles.
1. Hirshberg A, Srinivas SK. Epidemiology of maternal morbidity and mortality. Semin Perinatol. 2017;41:332–7.
2. Fetner T, Dion M, Heath M, Andrejek N, Newell SL, Stick M. Condom use in penile–vaginal intercourse among Canadian adults: results from the sex in Canada survey. PLoS ONE. 2020;15: e0228981.
3. World Health Organization. Family planning: a global handbook for providers. Geneva: World Health Organization, Johns Hopkins Bloomberg School of Public Health; 2018. p. 559–60.
4. Thomas S, Visakh P, Mathew AP. Advances in natural polymers. Adv Struct Mater. 2013;18(1):361–96.
5. Kowalski PS, Bhattacharya C, Afewerki S, Langer RS. Smart biomaterials: recent advances and future directions. ACS Biomater Sci Eng. 2018;4:3809–17.
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