Author:
Xiong Feng,Qin Zainen,Chen Haimin,Lan Qiumei,Wang Zetao,Lan Nihan,Yang Yuan,Zheng Li,Zhao Jinmin,Kai Dan
Abstract
AbstractDrug therapy of osteoarthritis (OA) is limited by the short retention and lacking of stimulus-responsiveness after intra-articular (IA) injection. The weak acid microenvironment in joint provides a potential trigger for controlled drug release systems in the treatment of OA. Herein, we developed an pH-responsive metal − organic frameworks (MOFs) system modified by hyaluronic acid (HA) and loaded with an anti-inflammatory protocatechuic acid (PCA), designated as MOF@HA@PCA, for the therapy of OA. Results demonstrated that MOF@HA@PCA could smartly respond to acidic conditions in OA microenvironment and gradually release PCA, which could remarkably reduce synovial inflammation in both IL-1β induced chondrocytes and the OA joints. MOF@HA@PCA also down-regulated the expression of inflammatory markers of OA and promoted the expression of cartilage-specific makers. This work may provide a new insight for the design of efficient nanoprobes for precision theranostics of OA.
Funder
National Key R&D Program of China
National Natural Science Fund of China
the Guangxi Key Research and Development Plan
the Distinguished Young Scholars Program of Guangxi Medical University
the Basic ability enhancement project for young and middle-aged teachers of universities in Guangxi
the project of Guangxi Ren Cai Gao Di
Publisher
Springer Science and Business Media LLC
Subject
Pharmaceutical Science,Applied Microbiology and Biotechnology,Biomedical Engineering,Molecular Medicine,Medicine (miscellaneous),Bioengineering
Cited by
55 articles.
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