Author:
Yang Zhangze,You Yuxin,Liu Xiangyu,Wan Quan,Xu Zongpu,Shuai Yajun,Wang Jie,Guo Tingbiao,Hu Jiaqi,Lv Junhui,Zhang Meng,Yang Mingying,Mao Chuanbin,Yang Shuxu
Abstract
AbstractBrain damage is a common tissue damage caused by trauma or diseases, which can be life-threatening. Stem cell implantation is an emerging strategy treating brain damage. The stem cell is commonly embedded in a matrix material for implantation, which protects stem cell and induces cell differentiation. Cell differentiation induction by this material is decisive in the effectiveness of this treatment strategy. In this work, we present an injectable fibroin/MXene conductive hydrogel as stem cell carrier, which further enables in-vivo electrical stimulation upon stem cells implanted into damaged brain tissue. Cell differentiation characterization of stem cell showed high effectiveness of electrical stimulation in this system, which is comparable to pure conductive membrane. Axon growth density of the newly differentiated neurons increased by 290% and axon length by 320%. In addition, unfavored astrocyte differentiation is minimized. The therapeutic effect of this system is proved through traumatic brain injury model on rats. Combined with in vivo electrical stimulation, cavities formation is reduced after traumatic brain injury, and rat motor function recovery is significantly promoted.
Graphical Abstract
Funder
National Natural Science Foundation of China
Zhejiang Provincial Natural Science Foundation of China
National Postdoctoral Science Foundation of China
Zhejiang University K. P. Chao’s High Technology Development Foundation
Zhejiang Provincial Science and Technology Plan
Publisher
Springer Science and Business Media LLC
Cited by
3 articles.
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