Prediabetes remission after bariatric surgery: a 4-years follow-up study
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Published:2024-01-11
Issue:1
Volume:24
Page:
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ISSN:1472-6823
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Container-title:BMC Endocrine Disorders
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language:en
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Short-container-title:BMC Endocr Disord
Author:
Borges-Canha MartaORCID, Neves João Sérgio, Silva Maria Manuel, Mendonça Fernando, Moreno Telma, Ribeiro Sara, Vale Catarina, Gonçalves Juliana, Ferreira Helena Urbano, Gil-Santos Sara, Calheiros Raquel, Meira Inês, Menino João, Guerreiro Vanessa, Pedro Jorge, Sande Ana, Souto Selma B., da Costa Eduardo Lima, Carvalho Davide, Freitas Paula, , Preto John Rodrigues, Sousa Hugo Miguel Santos, Pinho André Manuel Costa, Galego Carla Cristina Oliveira Rodrigues T, Correia Maria Flora Ferreira Sampaio Carval, Gil Cidália Fátima Castro, Melim Diva Bizarro Figueiredo, Pinto Eduardo Gil Ferreira Rodrigues, Silva Marco António Costa, Martins Cristina Sarmento Pontes, Pereira Luís Miguel Gonçalves, Magalhães Inês Vasconcelos Sousa, Brandão Isabel Maria Boavista Vieira Marque, Andrade Sertório Manuel Freitas, Nunes Patrícia Maria Lopes
Abstract
Abstract
Background
Bariatric surgery leads to weight loss and to cardiometabolic risk improvement. Although prediabetes remission after bariatric surgery is biologically plausible, data on this topic is scarce. We aimed to assess prediabetes remission rate and clinical predictors of remission in a 4 year follow up period.
Methods
Observational longitudinal study including patients with obesity and prediabetes who had undergone bariatric surgery in our centre. Prediabetes was defined as having a baseline glycated haemoglobin (A1c) between 5.7% and 6.4% and absence of anti-diabetic drug treatment. We used logistic regression models to evaluate the association between the predictors and prediabetes remission rate.
Results
A total of 669 patients were included, 84% being female. The population had a mean age of 45.4 ± 10.1 years-old, body mass index of 43.8 ± 5.7 kg/m2, and median A1c of 5.9 [5.8, 6.1]%. After bariatric surgery, prediabetes remission rate was 82%, 73%, 66%, and 58%, respectively in the 1st, 2nd, 3rd, and 4th years of follow-up. Gastric sleeve (GS) surgery was associated with higher prediabetes remission rate than Roux-en-Y gastric bypass surgery in the 3rd year of follow-up. Men had a higher remission rate than women, in the 1st and 3nd years of follow-up in the unadjusted analysis. Younger patients presented a higher remission rate comparing to older patients in the 3rd year of follow-up.
Conclusion
We showed a high prediabetes remission rate after bariatric surgery. The remission rate decreases over the follow-up period, although most of the patients maintain the normoglycemia. Prediabetes remission seems to be more significant in patients who had undergone GS, in male and in younger patients.
Publisher
Springer Science and Business Media LLC
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