Abstract
Abstract
Background
Agenesis of the dorsal pancreas (ADP) is clinically rare, and it is usually accompanied by abdominal pain. Various disorders of glucose metabolism associating with ADP have been reported, but there are only two studies reporting a correlation between ADP and DKA in English literature.
Case presentation
We present a case of a patient with ADP accompanied by abdominal pain and diabetic ketoacidosis as the initial clinical presentation. A 30-year-old man presented with a 3-month history of recurrent onset of persistent mild epigastric pain, which worsen when eating. Laboratory tests revealed metabolic acidosis, hyperglycemia, and ketonuria. Phase contrast CT and MRCP showed the absence of the body and tail of the pancreas, as well as the dorsal pancreatic duct. The C-peptide release test indicated β-cell dysfunction. A combination therapy of insulin, pancreatic enzyme supplements, and mosapride citrate were administrated and the pain gradually resolved.
Conclusions
As glucose metabolism disorders can vary across different individuals, we advise clinicians to consider the diagnosis of ADP for a patient who presents with a glucose metabolism disorder accompanied by abdominal pain, pancreatitis or steatorrhea.
Publisher
Springer Science and Business Media LLC
Subject
General Medicine,Endocrinology, Diabetes and Metabolism
Reference33 articles.
1. Association AD. Classification and diagnosis of diabetes: standards of medical care in diabetes-2019. Diabetes Care. 2019;42(Suppl 1):S13–28.
2. Buzzetti R, Zampetti S, Maddaloni E. Adult-onset autoimmune diabetes: current knowledge and implications for management. Nat Rev Endocrinol. 2017;13(11):674–86.
3. Devarbhavi PK, Bhagwat KA, Patil TCR, Murthy V, Chakravarthi S. Dorsal agenesis of pancreas manifesting clinically as diabetic ketoacidosis: a rare case study. Ann Res & Rev in Biol. 2014;4(16):2579–86.
4. Sohn TS, Kim HH, Seo W, Lee KP, Seok H, Son HS. Diabetic ketoacidosis, severe hypertriglyceridemia, and acute pancreatitis in a patient with agenesis of the dorsal pancreas. Endocr Rev 2018, 39(2):Supplement 1.
5. Caetano LA, Santana LS, Costa-Riquetto AD, Lerario AM, Nery M, Nogueira GF, Ortega CD, Rocha MS, Jorge AAL, Teles MG. PDX1-MODY and dorsal pancreatic agenesis: new phenotype of a rare disease. Clin Genet. 2018;93(2):382–6.
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献