Author:
Xu Xiaofang,Song Binbin,Zhang Qiuliang,Qi Weibo,Xu Yufen
Abstract
AbstractHsa_circ_0022383 (circ_0022383) is a newly discovered circRNA. Its functions and relevant molecular mechanisms in tumorigenesis have not been reported. Here we aimed to explore how circ_0022383 regulates the tumorigenesis of non-small-cell lung cancer (NSCLC). We found thatcirc_0022383 expression was dramatically elevated in NSCLC tissues and cell lines. Upregulation of circ_0022383 was associated with poor prognosis in NSCLC patients. Silencing of circ_0022383 repressed cell proliferation and migration in vitro and inhibited oncogenesis and tumor metastasis in vivo. Moreover, our results discovered that circ_0022383 was mainly located in the cytoplasm of NSCLC cells. Mechanistically, circ_0022383 sponged miR-495-3p to modulate KPNA2 expression, thereby regulating NSCLC tumorigenesis and progression. In conclusion, our study demonstrates that circ_0022383 facilitates NSCLC tumorigenesis by regulating the miR-495-3p/KPNA2 axis, providing new insights into NSCLC development.
Funder
Natural Science Foundation of Zhejiang province
Science and technology project of Jiaxing
Key Discipline of Jiaxing Medicine Construction Project
The Jiaxing Key Laboratory of Precision Treatment for Lung Cancer, Scientific Technology Plan Program for Healthcare in Zhejiang Province
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Genetics,Oncology