Abstract
AbstractAntisense long non-coding RNAs (antisense lncRNAs), transcribed from the opposite strand of genes with either protein coding or non-coding function, were reported recently to play a crucial role in the process of tumor onset and development. Functionally, antisense lncRNAs either promote or suppress cancer cell proliferation, migration, invasion, and chemoradiosensitivity. Mechanistically, they exert their regulatory functions through epigenetic, transcriptional, post-transcriptional, and translational modulations. Simultaneously, because of nucleotide sequence complementarity, antisense lncRNAs have a special role on its corresponding sense gene. We highlight the functions and molecular mechanisms of antisense lncRNAs in cancer tumorigenesis and progression. We also discuss the potential of antisense lncRNAs to become cancer diagnostic biomarkers and targets for tumor treatment.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Hunan Province
Huxiang Young Talents Plan Project of Hunan Province
the New Xiangya Talent Projects of the Third Xiangya Hospital of Central South University
the Scientific Projects of Changsha Administration of Science &Technology
the Scientific Projects of Health Commission of Hunan Province
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Genetics,Oncology
Cited by
30 articles.
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