High-efficiency expression and secretion of human FGF21 in Bacillus subtilis by intercalation of a mini-cistron cassette and combinatorial optimization of cell regulatory components-Reference-Cited by-同舟云学术

High-efficiency expression and secretion of human FGF21 in Bacillus subtilis by intercalation of a mini-cistron cassette and combinatorial optimization of cell regulatory components

Published:2019-01-28 Issue:1 Volume:18 Page:
ISSN:1475-2859
Container-title:Microbial Cell Factories
language:en
Short-container-title:Microb Cell Fact

Author:

Li Dandan,Fu Gang,Tu Ran,Jin Zhaoxia,Zhang Dawei^ORCID

Funder

Tianjin Science Fund for Distinguished Young Scholars

Nature Science Foundation of Tianjin

Tianjin Science and Technology project

the Key Projects in the Tianjin Science & Technology Pillar Program

the Key Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences.

Natural Science Foundation of China

Natural Science Foundation of Liaoning Province of China

the Science and Technology Service Network (STS) Initiative of Chinese Academy of Sciences

National Key R&D Program of China

Publisher

Springer Science and Business Media LLC

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

http://link.springer.com/content/pdf/10.1186/s12934-019-1066-4.pdf

Reference62 articles.

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2. Kharitonenkov A, Beals JM, Micanovic R, Strifler BA, Rathnachalam R, Wroblewski VJ, Li S, Koester A, Ford AM, Coskun T, et al. Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319. Plos One. 2013;8:e58575.

3. Kharitonenkov A, Larsen P. FGF21 reloaded: challenges of a rapidly growing field. Trends Endocrinol Metab. 2011;22:81–6.

4. Berglund ED, Li CY, Bina HA, Lynes SE, Michael MD, Shanafelt AB, Kharitonenkov A, Wasserman DH. Fibroblast growth factor 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivity. Endocrinology. 2009;150:4084–93.

5. Zimmet P, Alberti KG, Shaw J. Global and societal implications of the diabetes epidemic. Nature. 2001;414:782–7.

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