Author:
González-Suárez Begoña,Pagés Mario,Araujo Isis Karina,Romero Cristina,Rodríguez de Miguel Cristina,Ayuso Juan Ramón,Pozo Àngels,Vila-Casadesús Maria,Serradesanferm Anna,Ginès Àngels,Fernández-Esparrach Glòria,Pellisé Maria,López-Cerón María,Flores David,Córdova Henry,Sendino Oriol,Grau Jaume,Llach Josep,Serra-Burriel Miquel,Cárdenas Andrés,Balaguer Francesc,Castells Antoni
Abstract
Abstract
Background
Colon capsule endoscopy (CCE) and CT colonography (CTC) are minimally invasive techniques for colorectal cancer (CRC) screening. Our objective is to compare CCE and CTC for the identification of patients with colorectal neoplasia among participants in a CRC screening programme with positive faecal immunochemical test (FIT). Primary outcome was to compare the performance of CCE and CTC in detecting patients with neoplastic lesions.
Methods
The VICOCA study is a prospective, single-centre, randomised trial conducted from March 2014 to May 2016; 662 individuals were invited and 349 were randomised to CCE or CTC before colonoscopy. Endoscopists were blinded to the results of CCE and CTC.
Results
Three hundred forty-nine individuals were included: 173 in the CCE group and 176 in the CTC group. Two hundred ninety individuals agreed to participate: 147 in the CCE group and 143 in the CTC group. In the intention-to-screen analysis, sensitivity, specificity and positive and negative predictive values for the identification of individuals with colorectal neoplasia were 98.1%, 76.6%, 93.7% and 92.0% in the CCE group and 64.9%, 95.7%, 96.8% and 57.7% in the CTC group. In terms of detecting significant neoplastic lesions, the sensitivity of CCE and CTC was 96.1% and 79.3%, respectively. Detection rate for advanced colorectal neoplasm was higher in the CCE group than in the CTC group (100% and 93.1%, respectively; RR = 1.07; p = 0.08). Both CCE and CTC identified all patients with cancer. CCE detected more patients with any lesion than CTC (98.6% and 81.0%, respectively; RR = 1.22; p = 0.002).
Conclusion
Although both techniques seem to be similar in detecting patients with advanced colorectal neoplasms, CCE is more sensitive for the detection of any neoplastic lesion.
Trial registration
ClinicalTrials.gov Identifier: NCT02081742. Registered: September 16, 2013.
Publisher
Springer Science and Business Media LLC
Cited by
29 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献