Your height affects your health: genetic determinants and health-related outcomes in Taiwan

Author:

Chiou Jian-Shiun,Cheng Chi-Fung,Liang Wen-Miin,Chou Chen-Hsing,Wang Chung-Hsing,Lin Wei-De,Chiu Mu-Lin,Cheng Wei-Chung,Lin Cheng-Wen,Lin Ting-Hsu,Liao Chiu-Chu,Huang Shao-Mei,Tsai Chang-Hai,Lin Ying-JuORCID,Tsai Fuu-Jen

Abstract

Abstract Background Height is an important anthropometric measurement and is associated with many health-related outcomes. Genome-wide association studies (GWASs) have identified hundreds of genetic loci associated with height, mainly in individuals of European ancestry. Methods We performed genome-wide association analyses and replicated previously reported GWAS-determined single nucleotide polymorphisms (SNPs) in the Taiwanese Han population (Taiwan Biobank; n = 67,452). A genetic instrument composed of 251 SNPs was selected from our GWAS, based on height and replication results as the best-fit polygenic risk score (PRS), in accordance with the clumping and p-value threshold method. We also examined the association between genetically determined height (PRS251) and measured height (phenotype). We performed observational (phenotype) and genetic PRS251 association analyses of height and health-related outcomes. Results GWAS identified 6843 SNPs in 89 genomic regions with genome-wide significance, including 18 novel loci. These were the most strongly associated genetic loci (EFEMP1, DIS3L2, ZBTB38, LCORL, HMGA1, CS, and GDF5) previously reported to play a role in height. There was a positive association between PRS251 and measured height (p < 0.001). Of the 14 traits and 49 diseases analyzed, we observed significant associations of measured and genetically determined height with only eight traits (p < 0.05/[14 + 49]). Height was positively associated with body weight, waist circumference, and hip circumference but negatively associated with body mass index, waist-hip ratio, body fat, total cholesterol, and low-density lipoprotein cholesterol (p < 0.05/[14 + 49]). Conclusions This study contributes to the understanding of the genetic features of height and health-related outcomes in individuals of Han Chinese ancestry in Taiwan.

Funder

China Medical University, Taiwan

China Medical University Hospital

Ministry of Science and Technology, Taiwan

Publisher

Springer Science and Business Media LLC

Subject

General Medicine

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