Author:
Hua Yuze,Yang Sen,Zhang Yalu,Li Jiayi,Wang Mengyi,Yeerkenbieke Palashate,Liao Quan,Liu Qiaofei
Abstract
AbstractFerroptosis, a novel form of cell death triggered by iron-dependent phospholipid peroxidation, presents significant therapeutic potential across diverse cancer types. Central to cellular metabolism, the metabolic pathways associated with ferroptosis are discernible in both cancerous and immune cells. This review begins by delving into the intricate reciprocal regulation of ferroptosis between cancer and immune cells. It subsequently details how factors within the tumor microenvironment (TME) such as nutrient scarcity, hypoxia, and cellular density modulate ferroptosis sensitivity. We conclude by offering a comprehensive examination of distinct immunophenotypes and environmental and metabolic targets geared towards enhancing ferroptosis responsiveness within the TME. In sum, tailoring precise ferroptosis interventions and combination strategies to suit the unique TME of specific cancers may herald improved patient outcomes.
Funder
Innovative Research Group Project of the National Natural Science Foundation of China
CAMS Innovation Fund for Medical Sciences
Natural Science Foundation of Beijing Municipality
Youth Foundation of Peking Union Medical College Hospital
Publisher
Springer Science and Business Media LLC