Coexisting choroidal neovascularization and active retinochoroiditis—an uncommon presentation of ocular toxoplasmosis

Author:

Hegde Sharat,Relhan Nidhi,Pathengay Avinash,Bawdekar Abhishek,Choudhury Himadri,Jindal Animesh,Flynn Harry W

Abstract

Abstract Background Choroidal neovascularization during the active stage of Toxoplasma retinochoroiditis is an uncommon clinical presentation. The authors retrospectively reviewed medical charts of patients with coexisting choroidal neovascular membrane and active Toxoplasma retinochoroiditis. Findings Three patients presented with coexisting choroidal neovascular membrane and active Toxoplasma retinochoroiditis. All lesions had adjacent subretinal hemorrhage. The diagnosis was confirmed based on clinical presentation, fundus fluorescein angiography (FFA), and optical coherence tomography (OCT) findings. The patients were managed with a combination of treatments including intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF), oral anti-Toxoplasma treatment, and oral corticosteroids. In all patients, the retinitis lesion resolved in 6 weeks and the coexisting choroidal neovascular membrane resolved over 6 to 12 weeks. Conclusions Recurrences in Toxoplasma retinochoroiditis are common as satellite lesions adjacent to an old atrophic scar. Coexisting choroidal neovascularization with active Toxoplasma retinochoroiditis is an important presentation and should be suspected in the presence subretinal hemorrhage and managed with a combination of anti-Toxoplasma treatment and intravitreal anti-VEGF.

Publisher

Springer Science and Business Media LLC

Subject

Infectious Diseases,Ophthalmology

Reference20 articles.

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2. Cotliar AM, Friedman AH (1982) Subretinal neovascularisation in ocular toxoplasmosis. Br J Ophthalmol 66:524–529

3. Noble KG, Carr RE (1982) Toxoplasma retinochoroiditis. Ophthalmology 89:1289–1290

4. Friedmann CT, Knox DL (1969) Variations in recurrent active toxoplasmic retinochoroiditis. Arch Ophthalmol 81:481–493

5. Desmonts G, Couvreur J (1974) Toxoplasmosis in pregnancy and its transmission to the fetus. Bull N Y Acad Med 50:146–159

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