Author:
Fousse Samantha L.,Tyrrell William D.,Dentino Mariellen E.,Abrams Frances L.,Rosenthal Steven L.,Stern Joshua A.
Abstract
Abstract
Background
Atrial fibrillation (AF) is the most common arrhythmia in dogs. The Irish Wolfhound breed has a high prevalence of AF making them an ideal breed to investigate possible genetic contributions to this disease. The aim of this study was to perform a heritability analysis in North American Irish Wolfhounds using phenotype data from cardiac screenings performed between 2000 and 2019 in order to determine how much of this disease can be attributed to genetics compared to environmental causes. The second aim was to determine the disease mode of inheritance to help inform prevention and breeding practices.
Results
There were 327 Irish Wolfhounds diagnosed with AF and 136 Irish Wolfhounds over 8 years of age without AF. The estimated mean (95% confidence interval) heritability of AF in Irish Wolfhounds was 0.69 (0.50–0.86). The pedigree was consistent with a dominant mode of inheritance.
Conclusion
Results of this study indicate a strong genetic contribution to AF in Irish Wolfhounds and suggest that future research to identify causative genetic mutations is warranted.
Funder
National Heart, Lung, and Blood Institute
Novartis Institutes for BioMedical Research
Publisher
Springer Science and Business Media LLC
Reference37 articles.
1. Noszczyk-Nowak A, Michałek M, Kałuza E, Cepiel A, Pasławska U. Prevalence of arrhythmias in dogs examined between 2008 and 2014. J Vet Res. 2017;61(1):103–10.
2. Brundel BJJM, Melnyk P, Rivard L, Nattel S. The pathology of atrial fibrillation in dogs. J Vet Cardiol. 2005;7(2):121–9.
3. Saunders AB, Gordon SG, Miller MW. Canine atrial fibrillation. Compend Contin Educ Vet. 2009;31(11):E1–9.
4. Bohn F. Atrial fibrillation in dogs. Br Vet J. 1971;127:485–96.
5. Patterson DF, Detweiler DK, Hubben K, Botts RP. Spontaneous abnormal cardiac arrhythmias and conduction disturbances in the dog. A clinical and pathologic study of 3,000 dogs. Am J Vet Res. 1961;22:355.
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献