MRISCs protect colonic stem cells from inflammatory damage-Reference-Cited by-同舟云学术

MRISCs protect colonic stem cells from inflammatory damage

Published:2021-06-03 Issue:1 Volume:10 Page:
ISSN:2045-9769
Container-title:Cell Regeneration
language:en
Short-container-title:Cell Regen

Author:

Zhu Guoli,Xi Rongwen^ORCID

Abstract

AbstractIncreasing evidence suggest functional roles of subepithelial mesenchymal niche cells in maintaining intestinal stem cells and in modulating the pathogenesis of various intestinal diseases in mammals. A recent study reported the discovery of a new population of stromal cells in mice termed MAP3K2-Regulated Intestinal Stromal Cells (MRISCs); these cells reside at the base of colonic crypt and function to protect colonic stem cells during colonic inflammation by expressing the Wnt agonist R-spondin1 (Rspo1).

Funder

Ministry of Science and Technology of the People's Republic of China

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Developmental Biology

Link

https://link.springer.com/content/pdf/10.1186/s13619-021-00086-4.pdf

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