Author:
Ma Juan,Wei Zhongcao,Wang Qian,Lu Xiaolan,Zhou Zhihua,Li Ruohan,Shu Qiuai,Liu Yixin,Wang Jinhai,Liu Na,Shi Haitao
Abstract
Abstract
Background
Recent studies have shown that chronic kidney disease (CKD) prevalence is significantly higher in patients with hepatic steatosis (HS); however, it remains unclear whether HS is associated with serum creatinine (SCr). We aimed to explore the association between SCr levels and HS in a Chinese population.
Methods
We performed a cross-sectional study among 56,569 Chinese individuals. SCr level, other clinical and laboratory parameters, abdominal ultrasound and noninvasive fibrosis scores were extracted, and the fibrosis 4 score (FIB-4) was calculated.
Results
A total of 27.1% of the subjects had HS. After 1:1 propensity score matching (PSM) according to sex and age, we included 13,301 subjects with HS and 13,301 subjects without HS. SCr levels were significantly higher in the HS group than in the non-HS group [73.19 ± 15.14(μmoI/L) vs. 71.75 ± 17.49(μmoI/L), p < 0.001]. Univariate and multivariate regression analyses showed a positive association between SCr and the prevalence of HS. Stepwise regression analysis showed that the association between SCr and HS was independent of other metabolic syndrome components. The prevalence of HS increased significantly with increasing SCr levels. Metabolism-related indicators and liver enzymes were significantly higher in the HS group than in the non-HS group; furthermore, these parameters increased with increasing SCr levels. FIB-4 was significantly higher in the HS group than in the non-HS group but did not show an increasing trend with increasing SCr levels.
Conclusions
Our results showed an independent association between SCr level and HS risk in a Chinese population.
Funder
National Key Research and Development Program of China
Key Research and Development Program of Shaanxi Province of China; Shaanxi Province, China
Publisher
Springer Science and Business Media LLC
Subject
Gastroenterology,General Medicine
Cited by
4 articles.
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