In situ genetic engineering of host T-cells based on acellular scaffold strategy: a big but also small step for solid tumor immunotherapy

Author:

Han Shu-Yan,Zhao Zi-Xuan,Wu Jun

Funder

National Natural Science Foundation of China

Guangzhou Science and Technology Program City-University Joint Funding Project

Postdoctoral Fellowship Program of CPSF

Publisher

Springer Science and Business Media LLC

Reference6 articles.

1. Zhu C, Wu Q, Sheng T, Shi J, Shen X, Yu J, et al. Rationally designed approaches to augment CAR-T therapy for solid tumor treatment. Bioact Mater. 2024;33:377–95.

2. Liu H, Shen W, Liu W, Yang Z, Yin D, Xiao C. From oncolytic peptides to oncolytic polymers: a new paradigm for oncotherapy. Bioact Mater. 2024;31:206–30.

3. Dandia HY, Pillai MM, Sharma D, Suvarna M, Dalal N, Madhok A, et al. Acellular scaffold-based approach for in situ genetic engineering of host T-cells in solid tumor immunotherapy. Mil Med Res. 2024;11(1):3.

4. Dagher OK, Posey AD Jr. Forks in the road for CAR T and CAR NK cell cancer therapies. Nat Immunol. 2023;24(12):1994–2007.

5. Walsh LA, Quail DF. Decoding the tumor microenvironment with spatial technologies. Nat Immunol. 2023;24(12):1982–93.

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