Targeting NR1D1 in organ injury: challenges and prospects-Reference-Cited by-同舟云学术

Targeting NR1D1 in organ injury: challenges and prospects

Published:2023-12-11 Issue:1 Volume:10 Page:
ISSN:2054-9369
Container-title:Military Medical Research
language:en
Short-container-title:Military Med Res

Author:

Zhang-sun Zi-Yin,Xu Xue-Zeng,Escames Germaine,Lei Wang-Rui,Zhao Lin,Zhou Ya-Zhe,Tian Ye,Ren Ya-Nan,Acuña-Castroviejo Darío,Yang Yang^ORCID

Abstract

AbstractNuclear receptor subfamily 1, group D, member 1 (NR1D1, also known as REV-ERBα) belongs to the nuclear receptor (NR) family, and is a heme-binding component of the circadian clock that consolidates circadian oscillators. In addition to repressing the transcription of multiple clock genes associated with circadian rhythms, NR1D1 has a wide range of downstream target genes that are intimately involved in many physiopathological processes, including autophagy, immunity, inflammation, metabolism and aging in multiple organs. This review focuses on the pivotal role of NR1D1 as a key transcription factor in the gene regulatory network, with particular emphasis on the milestones of the latest discoveries of NR1D1 ligands. NR1D1 is considered as a promising drug target for treating diverse diseases and may contribute to research on innovative biomarkers and therapeutic targets for organ injury-related diseases. Further research on NR1D1 ligands in prospective human trials may pave the way for their clinical application in many organ injury-related disorders.

Funder

National Natural Science Foundation of China

Postdoctoral Research Foundation of China

Research Plan Project of Shaanxi Institute of Basic Science

High-end Foreign Expert Introduction Program of National Science and Technology

Qinchuangyuan Traditional Chinese Medicine Innovation Research and Development Transformation Project

Publisher

Springer Science and Business Media LLC

Subject

General Medicine

Link

https://link.springer.com/content/pdf/10.1186/s40779-023-00495-3.pdf

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