Molecular and clinical characterization of PTRF in glioma via 1,022 samples

Author:

Sun Si,Yang Changlin,Wang Kuanyu,Huang Ruoyu,Zhang Ke-nan,Liu Yanwei,Cao Zhi,Zhao Zheng,Jiang Tao

Abstract

AbstractPolymerase I and transcript release factor (PTRF) plays a role in the regulation of gene expression and the release of RNA transcripts during transcription, which have been associated with various human diseases. However, the role of PTRF in glioma remains unclear. In this study, RNA sequencing (RNA-seq) data (n = 1022 cases) and whole-exome sequencing (WES) data (n = 286 cases) were used to characterize the PTRF expression features. Gene ontology (GO) functional enrichment analysis was used to assess the biological implication of changes in PTRF expression. As a result, the expression of PTRF was associated with malignant progression in gliomas. Meanwhile, somatic mutational profiles and copy number variations (CNV) revealed the glioma subtypes classified by PTRF expression showed distinct genomic alteration. Furthermore, GO functional enrichment analysis suggested that PTRF expression was associated with cell migration and angiogenesis, particularly during an immune response. Survival analysis confirmed that a high expression of PTRF is associated with a poor prognosis. In summary, PTRF may be a valuable factor for the diagnosis and treatment target of glioma.

Funder

Beijing Hospitals Authority Youth Programme

Beijing Municipal Health Commission Fund

Brain Tumor Precision Diagnosis and Treatment and Translational Medicine Innovation Unit of Chinese Academy of Medical Sciences

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Genetics,Oncology

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