Author:
Narita Shintaro,Tsuchiya Norihiko,Kumazawa Teruaki,Maita Shinya,Numakura Kazuyuki,Obara Takashi,Tsuruta Hiroshi,Saito Mitsuru,Inoue Takamitsu,Horikawa Yohei,Satoh Shigeru,Nanjyo Hiroshi,Habuchi Tomonori
Abstract
Abstract
Background
To assess the outcome of neoadjuvant chemohormonal therapy comprising complete androgen blockade followed by treatment with docetaxel and estramustine phosphate before radical prostatectomy in Japanese patients with a high risk of localized prostate cancer (PCa).
Methods
Complete androgen blockade followed by 6 cycles of docetaxel (30 mg/m2) with estramustine phosphate (560 mg) were given to 18 PCa patients before radical prostatectomy. Subsequently, the clinical and pathological outcomes were analyzed.
Results
No patients had severe adverse events during chemohormonal therapy, and hence they were treated with radical prostatectomy. Two patients (11.1%) achieved pathological complete response. Surgical margins were negative in all patients. At a median follow-up of 18 months, 14 patients (77.8%) were disease-free without PSA recurrence. All 4 patients with PSA recurrence had pathologic T3b or T4 disease and 3 of these 4 patients had pathologic N1 disease.
Conclusion
We found that neoadjuvant chemohormonal therapy with complete androgen blockade followed by treatment with docetaxel and estramustine phosphate before radical prostatectomy was safe, feasible, and associated with favorable pathological outcomes in patients with a high risk of localized PCa.
Publisher
Springer Science and Business Media LLC
Cited by
51 articles.
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