Urachal mixed adenocarcinoma and small cell neuroendocrine carcinoma with widespread metastasis and resistance to chemotherapy: a case report-Reference-Cited by-同舟云学术

Urachal mixed adenocarcinoma and small cell neuroendocrine carcinoma with widespread metastasis and resistance to chemotherapy: a case report

Published:2024-06-14 Issue:1 Volume:19 Page:
ISSN:1746-1596
Container-title:Diagnostic Pathology
language:en
Short-container-title:Diagn Pathol

Author:

Obiedat Sarah,Murshed Khaled,Szabados Lajos,Al Rumaihi Khaled,Al Bozom Issam

Abstract

AbstractNeuroendocrine carcinoma arising from the urachus is extremely rare. We describe a case of a 33-year-old gentleman who presented with hematuria and diagnosed to have a composite adenocarcinoma and small cell neuroendocrine carcinoma arising from the urachus. The patient also had widespread metastasis at the time of presentation, therefore, he was referred for chemotherapy. However, the disease showed progression despite treatment. Recognition of neuroendocrine carcinoma component in urachal tumors, although rare, is very essential as this histologic type carries poor prognosis with aggressive clinical outcome.

Funder

Qatar National Library

Publisher

Springer Science and Business Media LLC

Link

https://link.springer.com/content/pdf/10.1186/s13000-024-01490-5.pdf

Reference14 articles.

1. Gleason JM, Bowlin PR, Bagli DJ, et al. A comprehensive review of pediatric urachal anomalies and predictive analysis for adult urachal adenocarcinoma. J Urol. 2015;193(2):632–6. https://doi.org/10.1016/j.juro.2014.09.004.

2. Ashley RA, Inman BA, Routh JC, Rohlinger AL, Husmann DA, Kramer SA. Urachal anomalies: a longitudinal study of Urachal remnants in children and adults. J Urol. 2007;178(4 SUPPLEMENT):1615–8. https://doi.org/10.1016/j.juro.2007.03.194.

3. Moreira I, Coelho S, Rodrigues Â, Patrão AS, Maurício MJ. Urachal carcinoma: a case of a rare neoplasm. Curr Probl Cancer. 2021;45(6):100711. https://doi.org/10.1016/j.currproblcancer.2021.100711.

4. Wright JL, Porter MP, Li CI, Lange PH, Lin DW. Differences in survival among patients with urachal and nonurachal adenocarcinomas of the bladder. Cancer. 2006;107(4):721–8. https://doi.org/10.1002/cncr.22059.

5. Paner GP, Lopez-Beltran A, Sirohi D, Amin MB. Updates in the pathologic diagnosis and classification of epithelial neoplasms of urachal origin. Adv Anat Pathol. 2016;23(2):71–83. https://doi.org/10.1097/PAP.0000000000000110.