Abstract
AbstractRadiation-induced lung injury (RILI) is one of the most common complications associated with radiotherapy, characterized by early-stage radiation pneumonia and subsequent radiation pulmonary fibrosis. However, effective therapeutic strategies for RILI are currently lacking. Recently, an increasing number of studies reported that mesenchymal stem cells (MSCs) can enhance the regeneration of damaged tissue, modulate the inflammatory response, reduce the levels of fibrotic cytokines and reactive oxygen species, and inhibit epithelial-mesenchymal transformation. Interestingly, MSCs can also exert immunosuppressive effects, which highlights a new potential therapeutic activity of MSCs for managing RILI. Here, we reviewed the potential applications and therapeutic mechanisms of action of MSCs in RILI, which will represent a good compendium of information for researchers in this field.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Shandong Province of China
Developmental Project of Traditional Chinese Medical Sciences and Technology of Shandong Province
Innovation Project of Shandong Academy of Medical Sciences
Key R & D project of Shandong Province
Natural Science Foundation of Shandong Province
Shandong Provincial Medical and Health Science and Technology Development Project
Academic Promotion Programme of Shandong First Medical University
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Medicine,Medicine (miscellaneous)
Cited by
9 articles.
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