Abstract
Abstract
Background
Coronary artery disease (CAD) is the main cause of death in Egypt. Many LDL-R gene locus single nucleotide polymorphisms (SNP) are found to be associated with the risk of CAD. This research aimed to assess the allelic and genotypic frequencies of rs1122608 SNP and their association with the extent of vessel affection and lipid profile in a population of Egyptians.100 CAD patients and 100 healthy controls of Egyptians were included. PCR–RFLP was used to genotype rs1122608 SNPs.
Results
Significantly higher proportion of ‘T’ allele among patient (risk allele). This association is of low strength (ϕ lies between 0.1 and 0.3). A participant with ‘T’ allele has 1.95 times higher odds to exhibit CAD versus a participant with ‘G’ allele. Significantly higher proportion of ‘T/T’ genotype among cases versus control (risk genotype). This association is of low strength (Cramer’s V lies between 0.1 and 0.3). A participant with ‘T/T’ genotype has 4.5 times higher odds to exhibit CAD versus a participant with ‘G/G’. Gensini score showed no significant association with rs1122608 genotypes (p = 0.863).
Conclusions
The mutant GT and TT genotypes and minor T allele of rs1122608 were positively correlated with CAD and considered as independent risk factors for CAD.
Publisher
Springer Science and Business Media LLC
Reference30 articles.
1. Jamaldini H, Babanejad M, Mozaffari R et al (2014) Association of polymorphisms at LDLR locus with coronary artery disease independently from lipid profile. Acta Med Iran 52:352–359
2. Aggarwal K, Seth S, Dahiya K et al (2011) Ischemia modified albumin in patients of cardiac and noncardiacchest pain. Biomed Res 23(1):61–65
3. Hassanin A, Hassanein M, Bendary A et al (2020) Demographics, clinical characteristics, and outcomes among hospitalized heart failure patients across different regions of Egypt. Egypt Heart J 72(1):1–9. https://doi.org/10.1186/s43044-020-00082-0
4. Ali OS, Abdelgawad HM, Mohammed MS et al (2014) Ischemic heart diseases in Egypt: role of xanthine oxidase system and ischemia-modified albumin. Heart Vessels 29(5):629–637. https://doi.org/10.1056/NEJMoa054013
5. WHO (2018) https://www.worldlifeexpectancy.com/egypt-coronary-heart-disease