Clinical and DCE-CT signs in predicting microvascular invasion in cHCC-ICC

Author:

Liao Zhong-Jian,Lu Lun,Liu Yi-Ping,Qin Geng-geng,Fan Cun-geng,Liu Yan-Ping,Jia Ning-yang,Zhang Ling

Abstract

Abstract Background To predict the microvascular invasion (MVI) in patients with cHCC-ICC. Methods A retrospective analysis was conducted on 119 patients who underwent CT enhancement scanning (from September 2006 to August 2022). They were divided into MVI-positive and MVI-negative groups. Results The proportion of patients with CEA elevation was higher in the MVI-positive group than in the MVI-negative group, with a statistically significant difference (P = 0.02). The MVI-positive group had a higher rate of peritumoral enhancement in the arterial phase (P = 0.01) whereas the MVI-negative group had more oval and lobulated masses (P = 0.04). According to the multivariate analysis, the increase in CEA (OR = 10.15, 95% CI: 1.11, 92.48, p = 0.04), hepatic capsular withdrawal (OR = 4.55, 95% CI: 1.44, 14.34, p = 0.01) and peritumoral enhancement (OR = 6.34, 95% CI: 2.18, 18.40, p < 0.01) are independent risk factors for predicting MVI. When these three imaging signs are combined, the specificity of MVI prediction was 70.59% (series connection), and the sensitivity was 100% (parallel connection). Conclusions Our multivariate analysis found that CEA elevation, liver capsule depression, and arterial phase peritumoral enhancement were independent risk factors for predicting MVI in cHCC-ICC.

Funder

the Natural Science Foundation of Guangdong Province

the science and technology plan project of Ganzhou

Publisher

Springer Science and Business Media LLC

Subject

Radiology, Nuclear Medicine and imaging,Oncology,General Medicine,Radiological and Ultrasound Technology

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