Author:
Naranjo Oandy,Torices Silvia,Clifford Paul R.,Daftari Manav T.,Osborne Olivia M.,Fattakhov Nikolai,Toborek Michal
Abstract
AbstractWhile HIV-1 is primarily an infection of CD4 + T cells, there is an emerging interest towards understanding how infection of other cell types can contribute to HIV-associated comorbidities. For HIV-1 to cross from the blood stream into tissues, the virus must come in direct contact with the vascular endothelium, including pericytes that envelope vascular endothelial cells. Pericytes are multifunctional cells that have been recognized for their essential role in angiogenesis, vessel maintenance, and blood flow rate. Most importantly, recent evidence has shown that pericytes can be a target of HIV-1 infection and support an active stage of the viral life cycle, with latency also suggested by in vitro data. Pericyte infection by HIV-1 has been confirmed in the postmortem human brains and in lungs from SIV-infected macaques. Moreover, pericyte dysfunction has been implicated in a variety of pathologies ranging from ischemic stroke to diabetes, which are common comorbidities among people with HIV-1. In this review, we discuss the role of pericytes during HIV-1 infection and their contribution to the progression of HIV-associated comorbidities.
Funder
National Institute on Drug Abuse
National Institute of Neurological Disorders and Stroke
National Institute of Mental Health
Publisher
Springer Science and Business Media LLC
Subject
Infectious Diseases,Virology
Cited by
3 articles.
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