Author:
Fan Ruoxun,Liu Jie,Jia Zhengbin
Abstract
Abstract
Background
Running with the appropriate intensity may produce a positive influence on the mechanical properties of cortical bone structure. However, few studies have discussed the effects of different running intensities on the mechanical properties at different levels, especially at the micro-level, because the micromechanical parameters are difficult to measure experimentally.
Methods
An approach that combines finite element analysis and experimental data was proposed to predict a micromechanical parameter in the rat femoral cortical bone structure, namely, the micro-level failure strain. Based on the previous three-point bending experimental information, fracture simulations were performed on the femur finite element models to predict their failure process under the same bending load, and the micro-level failure strains in tension and compression of these models were back-calculated by fitting the experimental load–displacement curves. Then, the effects of different running intensities on the micro-level failure strain of rat femoral cortical bone structure were investigated.
Results
The micro-level failure strains of the cortical bone structures expressed statistical variations under different running intensities, which indicated that different mechanical stimuli of running had significant influences on the micromechanical properties. The greatest failure strain occurred in the cortical bone structure under low-intensity running, and the lowest failure strain occurred in the structure under high-intensity running.
Conclusions
Moderate and low-intensity running were effective in enhancing the micromechanical properties, whereas high-intensity running led to the weakening of the micromechanical properties of cortical bone. Based on these, the changing trends in the micromechanical properties were exhibited, and the effects of different running intensities on the fracture performance of rat cortical bone structures could be discussed in combination with the known mechanical parameters at the macro- and nano-levels, which provided the theoretical basis for reducing fracture incidence through running exercise.
Funder
The higher education basic science (natural science) research project of Jiangsu Province
Publisher
Springer Science and Business Media LLC
Subject
Radiology, Nuclear Medicine and imaging,Biomedical Engineering,General Medicine,Biomaterials,Radiological and Ultrasound Technology
Reference38 articles.
1. Li JW, Gong H. Fatigue behavior of cortical bone: a review. Acta Mech Sin. 2020;37(3):516–26.
2. Bowman L, Loucks AB. In vivo assessment of cortical bone fragility. Curr Osteoporos Rep. 2020;18(1):13–22.
3. Tarantino U, Rao C, Tempesta V, Gasbarra E, Feola M. Hip fractures in the elderly: the role of cortical bone. Injury. 2017;47(S4):107–11.
4. Tamakoshi K, Nishii Y, Minematsu A. Upward running is more beneficial than level surface or downslope running in reverting tibia bone degeneration in ovariectomized rats. J Musculoskel Neuron. 2018;18(4):493–500.
5. Berman AG, Hinton MJ, Wallace JM. Treadmill running and targeted tibial loading differentially improve bone mass in mice. Bone Rep. 2019;10: 100195.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献