Author:
Paulissen Genevieve,Rocks Natacha,Gueders Maud M,Crahay Celine,Quesada-Calvo Florence,Bekaert Sandrine,Hacha Jonathan,El Hour Mehdi,Foidart Jean-Michel,Noel Agnes,Cataldo Didier D
Abstract
Abstract
Lungs are exposed to the outside environment and therefore to toxic and infectious agents or allergens. This may lead to permanent activation of innate immune response elements. A
Disintegrin And Metalloproteinases (ADAMs) and ADAMs with Thrombospondin motifs (ADAMTS) are proteinases closely related to Matrix Metalloproteinases (MMPs). These multifaceted molecules bear metalloproteinase and disintegrin domains endowing them with features of both proteinases and adhesion molecules. Proteinases of the ADAM family are associated to various physiological and pathological processes and display a wide spectrum of biological effects encompassing cell fusion, cell adhesion, "shedding process", cleavage of various substrates from the extracellular matrix, growth factors or cytokines... This review will focus on the putative roles of ADAM/ADAMTS proteinases in airway diseases such as asthma and COPD.
Publisher
Springer Science and Business Media LLC
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