Author:
Zhong Ying,Zhang Zhiqun,Hu Youfang
Abstract
Abstract
Background
This study was to evaluate the combined effects of overweight/obesity and DAQS on the risk of hypertension in children and adolescents.
Methods
In this cross-sectional study, the data of 14,316 subjects were extracted from the National Health and Nutrition Examination Survey (NHANES). Multivariate logistic regression analysis was used to explore the associations of obesity and DAQS with the risk of hypertension. The combined effect of overweight/obesity and DAQS on the risk of hypertension was evaluated.
Results
Body mass index (BMI)-for-age < 85th percentile was associated with reduced risk of hypertension in children and adolescents [odds ratio (OR) = 0.48, 95% confidence interval (CI): 0.41–0.62]. No significant association between DAQS ≥ 3 and the risk of hypertension before and after the adjustment of confounders (P > 0.05). Subjects with BMI-for-age of < 85th percentile and DAQS < 3 was associated with decreased risk of hypertension (OR = 0.53, 95%CI: 0.35–0.79). People with BMI-for-age of < 85th percentile and DAQS ≥ 3 was correlated with decreased risk of hypertension (OR = 0.52, 95%CI: 0.36–0.74). Subgroup analysis revealed that in subjects aged ≥ 12 years, decreased risk of hypertension was observed in BMI-for-age < 85th percentile and DAQS < 3 group (OR = 0.48, 95%CI: 0.31–0.73) as well as BMI-for-age < 85th percentile and DAQS ≥ 3 group (OR = 0.47, 95%CI: 0.32–0.67). In boys, BMI-for-age < 85th percentile and DAQS < 3 group (OR = 0.45, 95%CI: 0.25–0.81) as well as BMI-for-age < 85th percentile and DAQS ≥ 3 group (OR = 0.40, 95%CI: 0.25–0.65) were correlated with decreased risk of hypertension.
Conclusion
Overweight/obesity and DAQS had combined effects on the risk of hypertension in children and adolescents, which implied that for children and adolescents with normal weight, to keep normal weight combined with high quality of diet might be recommended.
Funder
National Natural Science Foundation of China Grants
Natural Science Foundation of Zhejiang Province Grant
Publisher
Springer Science and Business Media LLC
Subject
Pediatrics, Perinatology and Child Health
Reference38 articles.
1. Riley M, Hernandez AK, Kuznia AL. High blood pressure in children and adolescents. Am Fam Physician. 2018;98:486–94.
2. Bruyne PD, Walle JV. Management of hypertension in children and adolescents. Acta Clin Belg. 2015;70:87–94.
3. Goodwin ET, Kipnis CM, Daly PL, Smith DK. Hypertensive conditions: hypertension in children and adolescents. FP Essent. 2022;522:18–24.
4. Hamdani G, Dagan A. Primary hypertension in children and adolescents. Harefuah. 2021;160:260–5.
5. de Simone G, Mancusi C, Hanssen H, Genovesi S, Lurbe E, Parati G, et al. Hypertension in children and adolescents. Eur Heart J. 2022;43:3290–301.