Recent progress of prognostic biomarkers and risk scoring systems in chronic lymphocytic leukemia

Author:

Yun Xiaoya,Zhang Ya,Wang Xin

Abstract

AbstractChronic lymphocytic leukemia (CLL) is the most prevalent adult leukemia with high heterogeneity in the western world. Thus, investigators identified a number of prognostic biomarkers and scoring systems to guide treatment decisions and validated them in the context of immunochemotherapy. A better understanding of prognostic biomarkers, including serum markers, flow cytometry outcomes, IGHV mutation status, microRNAs, chromosome aberrations and gene mutations, have contributed to prognosis in CLL. Del17p/ TP53 mutation, NOTCH1 mutation, CD49d, IGHV mutation status, complex karyotypes and microRNAs were reported to be of predictive values to guide clinical decisions. Based on the biomarkers above, classic prognostic models, such as the Rai and Binet staging systems, MDACC nomogram, GCLLSG model and CLL-IPI, were developed to improve risk stratification and tailor treatment intensity. Considering the presence of novel agents, many investigators validated the conventional prognostic biomarkers in the setting of novel agents and only TP53 mutation status/del 17p and CD49d expression were reported to be of prognostic value. Whether other prognostic indicators and models can be used in the context of novel agents, further studies are required.

Funder

National Natural Science Foundation of China

National Natural Science Foundation

Key Research and Development Program of Shandong Province

Technology Development Projects of Shandong Province

Taishan Scholars Program of Shandong Province

Shandong Provincial Engineering Research Center of Lymphoma

Key Laboratory for Kidney Regeneration of Shandong Province

Academic promotion programme of Shandong First Medical University

Shandong Provincial Hospital Youth Talent Plan

Shandong Provincial Hospital Research Incubation Fund

Publisher

Springer Science and Business Media LLC

Subject

Biochemistry (medical),Clinical Biochemistry,Molecular Medicine

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