Author:
Liang Haoyu,Song Zhi-Man,Zhong Zheng,Zhang Dengwei,Yang Wei,Zhou Le,Older Ethan A.,Li Jie,Wang Huan,Zeng Zhirui,Li Yong-Xin
Abstract
Abstract
Background
Microbes produce diverse secondary metabolites (SMs) such as signaling molecules and antimicrobials that mediate microbe-microbe interaction. Archaea, the third domain of life, are a large and diverse group of microbes that not only exist in extreme environments but are abundantly distributed throughout nature. However, our understanding of archaeal SMs lags far behind our knowledge of those in bacteria and eukarya.
Results
Guided by genomic and metabolic analysis of archaeal SMs, we discovered two new lanthipeptides with distinct ring topologies from a halophilic archaeon of class Haloarchaea. Of these two lanthipeptides, archalan α exhibited anti-archaeal activities against halophilic archaea, potentially mediating the archaeal antagonistic interactions in the halophilic niche. To our best knowledge, archalan α represents the first lantibiotic and the first anti-archaeal SM from the archaea domain.
Conclusions
Our study investigates the biosynthetic potential of lanthipeptides in archaea, linking lanthipeptides to antagonistic interaction via genomic and metabolic analyses and bioassay. The discovery of these archaeal lanthipeptides is expected to stimulate the experimental study of poorly characterized archaeal chemical biology and highlight the potential of archaea as a new source of bioactive SMs.
Funder
Shenzhen Basic Research General Programme
Research Grants Council of Hong Kong
Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory
Publisher
Springer Science and Business Media LLC
Subject
Microbiology (medical),Microbiology
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