Author:
Gkogkou Charalampos,Frangia Konstantina,Saif Muhammad W,Trigidou Rodoula,Syrigos Konstantinos
Abstract
Abstract
Necrosis and apoptosis represent two pathogenetically distinct types of cell death. Necrosis is associated with pathologic conditions while apoptosis is a physiological process of programmed cell death, which is associated with normal tissue growth and is frequently impaired in various forms of cancer. Tumor necrosis and apoptotic index (AI) have been previously evaluated as prognostic biomarkers in lung cancer, but their exact clinical value remains unclear. The aim of this study was to perform a systematic review of the MEDLINE literature on the prognostic significance of these histopathological markers in patients with non-small cell lung carcinoma (NSCLC). Although a substantial body of evidence suggests that tumor necrosis may be a strong predictor of aggressive tumor behavior and reduced survival in patients with NSCLC, the independent prognostic value of this biomarker remains to be firmly established. Furthermore, previous data on the prognostic significance of apoptotic index in NSCLC are relatively limited and largely controversial. More prospective studies are necessary in order to further validate tumor necrosis and AI as prognostic markers in NSCLC.
Publisher
Springer Science and Business Media LLC
Reference37 articles.
1. Cho S, Sung SW, Jheon S, Chung JH: Risk of Recurrence in Surgically Resected Stage I Adenocarcinoma of the Lung: Histopathologic and Immunohistochemical Analysis. Lung 2008, 186: 411-419. 10.1007/s00408-008-9116-4
2. Diaz D, Prieto A, Reyes E, Barcenilla H, Monserrat J, Alvarez-Mon M: Flow cytometry enumeration of apoptotic cancer cells by apoptotic rate. Methods Mol Biol 2008, 414: 23-33.
3. Dobashi Y, Goto A, Fukayama M, Abe A, Ooi A: Overexpression of CDK4/Cyclin D1, a possible mediator of apoptosis and an indicator of prognosis in human primary lung carcinoma. Int J Cancer 2004, 110: 532-541. 10.1002/ijc.20167
4. Dworakowska D, Jassem E, Jassem J, Karmolinski A, Lapinski M, Tomaszewski D, Rzyman W, Jaskiewicz K, Sworczak K, Grossman AB: Prognostic value of the apoptotic index analyzed jointly with selected cell cycle regulators and proliferation markers in non-small cell lung cancer. Lung Cancer 2009, 66: 127-133. 10.1016/j.lungcan.2009.01.008
5. Edinger AL, Thompson CB: Death by design: apoptosis, necrosis, and autophagy. Curr Opin Cell Biol 2004, 16: 663-669. 10.1016/j.ceb.2004.09.011
Cited by
34 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献