Loss of heterozygosity at thymidylate synthase locus in Barrett's metaplasia, dysplasia, and carcinoma sequences

Author:

Kuramochi Hidekazu,Uchida Kazumi,Peters Jeffery H,Shimizu Daisuke,Vallbohmer Daniel,Schneider Sylke,Danenberg Kathleen D,Danenberg Peter V

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Genetics,Oncology

Reference39 articles.

1. Danenberg PV: Thymidylate synthetase – a target enzyme in cancer chemotherapy. Biochim Biophys Acta. 1977, 473: 73-92.

2. Leichman CG, Lenz HJ, Leichman L, Danenberg K, Baranda J, Groshen S, Boswell W, Metzger R, Tan M, Danenberg PV: Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin. J Clin Oncol. 1997, 15: 3223-3229.

3. Salonga D, Danenberg KD, Johnson M, Metzger R, Groshen S, Tsao-Wei DD, Lenz HJ, Leichman CG, Leichman L, Diasio RB, Danenberg PV: Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase. Clin Cancer Res. 2000, 6: 1322-1327.

4. Kaneda S, Takeishi K, Ayusawa D, Shimizu K, Seno T, Altman S: Role in translation of a triple tandemly repeated sequence in the 5'-untranslated region of human thymidylate synthase mRNA. Nucleic Acids Res. 1987, 15: 1259-1270. 10.1093/nar/15.3.1259.

5. Ishida Y, Kawakami K, Tanaka Y, Kanehira E, Omura K, Watanabe G: Association of thymidylate synthase gene polymorphism with its mRNA and protein expression and with prognosis in gastric cancer. Anticancer Res. 2002, 22: 2805-2809.

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