Author:
Kim Sangwoo,Kim Yoon,Kim Chaehyun,Choi Won Il,Kim Byoung Soo,Hong Jinkee,Lee Hoik,Sung Daekyung
Abstract
AbstractThe present study proposes an innovative transdermal drug delivery system using ferrocene-incorporated fibers to enhance the bioavailability and therapeutic efficacy of ascorbyl tetraisopalmitate. Using electrospinning technology, the authors created ferrocene polymer fibers capable of highly efficient drug encapsulation and controlled release in response to reactive oxygen species commonly found in wound sites. The approach improves upon previous methods significantly by offering higher drug loading capacities and sustained release, directly targeting diseased cells. The results confirm the potential of ferrocene fibers for localized drug delivery, potentially reducing side effects and increasing patient convenience. The method could facilitate the application of bioactive compounds in medical textiles and targeted therapy.
Funder
the Korea Institute of Marine Science & Technology Promotion
the National Research Foundation of Korea
Korea Institute of Industrial Technology
Publisher
Springer Science and Business Media LLC