Author:
Takahashi Nana,Kiyota Naoki,Kunikata Hiroshi,Yamazaki Mai,Nishimura Takayuki,Shiga Yukihiro,Aoyagi Hisae,Shidomi Miwako,Tsuda Tomohiro,Ohtsuka Toshihiko,Tomida Takahiro,Nakazawa Toru
Abstract
Abstract
Background
The dysfunction of optic nerve head (ONH) hemodynamics has been suggested to be involved in the pathogenesis of normal-tension glaucoma (NTG). The aim of this study was to compare vasoreactivity in the ONH, nailfold, and facial skin in response to cold-water provocation in NTG patients and healthy controls.
Methods
We performed cold-water provocation in 14 eyes of 14 NTG patients and 15 eyes of 15 age-matched control subjects. Laser speckle flowgraphy-derived tissue-area mean blur rate (MT), skin blood flowmetry-derived pulse wave amplitude (PA), nailfold capillaroscopy-derived nailfold capillary diameter, and other clinical parameters were recorded at baseline and 4 and 6 min after the cold stimulus. We compared changes (as percentages) in these variables in the NTG and control subjects with a linear mixed-effects model and evaluated correlations between these changes with Spearman’s rank correlation coefficient.
Results
The interaction term between the NTG group (reference, control group) and the 4-min protocol step (reference, baseline) significantly affected the changes in MT, nailfold capillary diameter and PA (β = -9.51%, P = 0.017, β = -20.32%, P = 0.002; β = + 18.06%, P = 0.017, respectively). The change in MT was positively correlated with the change in nailfold capillary diameter, and negatively correlated with the change in PA (r = 0.39, P = 0.036; r = -0.40, P = 0.031, respectively).
Conclusion
NTG patients showed abnormal vasoconstriction in the ONH and nailfold and vasodilation in the facial skin in response to cold-water provocation.
Funder
JST COI
JSPS KAKENHI Grants-in-Aid for Scientific Research
JSPS KAKENHI Grants-in-Aid for Exploratory Research
Publisher
Springer Science and Business Media LLC
Subject
Ophthalmology,General Medicine
Cited by
1 articles.
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