Thymus vulgaris extract modulates dexamethasone induced liver injury and restores the hepatic antioxidant redox system

Abstract

AbstractBackgroundThe liver is the largest important organ and the site for essential biochemical reactions and detoxifying toxic substances in the human body. Long-term, high-dose dexamethasone administration can cause severe alterations in liver function. Therefore,Thymus vulgarisleave extract possess a modulatory role on dexamethasone-induced hepatotoxicity by attenuating antioxidant defense system.By subcutaneous route, animals will receive three doses per week for 8 weeks of dexamethasone (0.1 mg/kg. b. wt.) concomitant with oral administration of thyme aqueous extract (500 mg/kg b.wt.).ResultsDXM treatment led to a marked increase in the liver function enzyme activities that are successfully ameliorated by thyme aqueous extract. Thyme natural antioxidants augmented the antioxidant defense system that overcomes oxidative stress caused by dexamethasone. Conversely, although dexamethasone-treated animals rose lipid peroxidation, thyme extract pretreatment did the reverse.ConclusionHepatotoxicity and oxidative stress caused by dexamethasone might improve by thyme natural antioxidants.