Abstract
Abstract
Background
Metabolic syndrome (MetS) is significantly associated with the risk of cardiovascular disease and its prevalence is showing a trend of getting younger. Previous studies on the relationship between elements and MetS were mostly reported in adults with single element analysis, while reports in children with combined effects of multiple elements were very limited. The aim of this study is to investigate the association between whole blood Cu, Mg and Zn in both single and combined effects and MetS components in rural Chinese children aged 6–12 years based on the data from 2010–2012 China National Nutrition and Health Survey.
Methods
A total of 911 children (51.2% male, 48.7% female) aged 6–12 years were included. Basic characteristics and MetS component parameters were collected and determined by trained stuffs. Elements were detected by Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Multivariate logistic regression analysis was performed to examine the independent relationship between elements and MetS components.
Results
In single metal analysis, copper was positively associated with elevated waist (OR = 2.00, 1.18–3.28) and all of the metals were associated with elevated TG. And the comprehensive analysis of multiple elements were mostly consistent with the results of single element analysis (low Cu + high Zn with elevated TG (OR = 2.21, 1.18–4.13), high Cu + low Mg with elevated TG (OR = 0.40, 0.16–0.95), high Cu + high Mg with elevated waist (OR = 2.03, 1.26–3.27)), except the combination of Zn and Mg (high Zn + low Mg with reduced HDL-C (OR = 0.47, 0.28–0.77)).
Conclusions
Our study suggested Cu, Zn and Mg in children are indeed associated with metabolic syndrome components, whether in single element or multi-element combined analysis. The results will be confirmed through additional cohort research.
Funder
Study of Diet and Nutrition Assessment and Intervention Technology
Publisher
Springer Science and Business Media LLC
Subject
Nutrition and Dietetics,Endocrinology, Diabetes and Metabolism,Medicine (miscellaneous)
Reference36 articles.
1. Alberti KGMM, Eckel RH, Grundy SM, et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation, 2009;120:1640–5.
2. He Y, Zhao W, Zhao L, et al. The epidemic status of metabolic syndrome among Chinese adolescents aged 10–17 years in 2010–2012. Chin J Prev Med. 2017;38(2):212–5.
3. Ding G, He Y. Report on nutrition and health status of Chinese residents (2010–2013) No. 7 metabolic syndrome. Beijing: People’s Medical Publishing House; 2018. p. 46–7.
4. Freitas EPS, Cunha ATO, Aquino SLS, et al. Zinc status biomarkers and cardiometabolic risk factors in metabolic syndrome: a case control study. Nutrients. 2017;9:151.
5. Qu R, Jia Y, Liu J, et al. Dietary flavonoids, copper intake, and risk of metabolic syndrome in Chinese adults. Nutrients. 2018;10:150.
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