Author:
John Erica,Laskow Thomas C,Buchser William J,Pitt Bruce R,Basse Per H,Butterfield Lisa H,Kalinski Pawel,Lotze Michael T
Abstract
Abstract
Zinc is important. It is the second most abundant trace metal with 2-4 grams in humans. It is an essential trace element, critical for cell growth, development and differentiation, DNA synthesis, RNA transcription, cell division, and cell activation. Zinc deficiency has adverse consequences during embryogenesis and early childhood development, particularly on immune functioning. It is essential in members of all enzyme classes, including over 300 signaling molecules and transcription factors. Free zinc in immune and tumor cells is regulated by 14 distinct zinc importers (ZIP) and transporters (ZNT1-8). Zinc depletion induces cell death via apoptosis (or necrosis if apoptotic pathways are blocked) while sufficient zinc levels allows maintenance of autophagy. Cancer cells have upregulated zinc importers, and frequently increased zinc levels, which allow them to survive. Based on this novel synthesis, approaches which locally regulate zinc levels to promote survival of immune cells and/or induce tumor apoptosis are in order.
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Reference207 articles.
1. Rink L, Gabriel P: Zinc and the immune system. Proc Nutr Soc. 2000, 541-10.1017/S0029665100000781.
2. Wapnir AR: Protein Nutrition and Mineral Absorption. 1990, CRC Press, Boca Raton
3. Berdanier DC, Dwyer JT, Feldman EB: Handbook of Nutrition and Food. 2007, CRC Pres, Boca Raton
4. Raulin J: Chemical studies on vegetation. Annales des Sci Naturelles. 1869, 11: 93-99.
5. Sommer AL, Lipman CB: Evidence on indispensable nature of zinc and boron for higher green plants. Plant Physiol. 1926, 1: 231-10.1104/pp.1.3.231.
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