White-coat hypertension and incident end-stage renal disease in patients with non-dialysis chronic kidney disease: results from the C-STRIDE Study
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Published:2020-06-15
Issue:1
Volume:18
Page:
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ISSN:1479-5876
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Container-title:Journal of Translational Medicine
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language:en
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Short-container-title:J Transl Med
Author:
Wang Qin, Wang YuORCID, Wang Jinwei, Zhang Luxia, Zhao Ming-hui, Zhao Ming-Hui, Zhang Luxia, Wang Xiaoqin, Yuan Jun, Zhou Qiaoling, Yuan Qiongjing, Chen Menghua, Zhou Xiaoling, Fu Shuxia, Li Shaomei, Zha Yan, Huang Rongsai, Liu Zhangsuo, Zhang JunJun, Wang Li, Pu Lei, Liu Jian, Li Suhua, Xiong Zuying, Liang Wei, Zhao Jinghong, Mu Jiao, Lian Xiyan, Liao Yunjuan, Gan Hua, Liao Liping, Wang Rong, Lv Zhimei, Liao Yunhua, Pan Ling, Yang Xiaoping, Lin Zhifeng, Tong Zongwu, Zhu Yun, He Qiang, Wu Fuquan, Li Rong, Rong Kai, Wang Caili, Zhang Yanhui, Wang Yue, Tang Wen, Wu Hua, Zhao Ban, Li Rongshan, Wang Lihua, Li Detian, Du Feng, Wu Yonggui, Zhang Wei, Lin Shan, Xu Pengcheng, Lin Hongli, Hu Zhao, Pei Fei, Zhang Haisong, Gao Yan, Sun Luying, Li Xia, Wang Wenke, Lv Fengling, Wang Deguang, Wang Xuerong, Xu Dongmei, Tang Lijun, Ma Yingchun, Wang Tingting, Fu Ping, Wang Tingli, Xing Changying, Zhang Chengning, Xu Xudong, He Haidong, Liao Xiaohui, Xie Shuqin, Hu Guicai, Huang Lan,
Abstract
Abstract
Background
Controversy remains whether white coat hypertension (WCH) is associated with renal prognosis in patients with chronic kidney disease (CKD).
Methods
In the present multicenter, prospective study, we analyzed data of participants with CKD stage 1–4 from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE). WCH was defined according to two criteria as follows: A, clinical blood pressure (BP) ≥ 140/90 mm Hg and average 24-h ambulatory BP < 130/80 mm Hg; B, clinical BP ≥ 130/80 mm Hg and daytime ambulatory BP < 130/80 mm Hg. Renal outcome was defined as initiation of renal replacement therapy. The association of WCH with renal events was evaluated by Cox regression model.
Results
A total of 1714 patients with CKD were included in the present analysis. The mean age of the population was 48.9 ± 13.8 years and 56.8% were men. The mean baseline estimated glomerular filtration rate (eGFR) was 52.2 ± 30.1 ml/min/1.73 m2 and urinary protein was 1.0 (0.4, 2.4) g/day. The overall prevalence of WCH was 4.7% and 16.6% according to criteria A and B, respectively. Incidence rates of renal events were 49.58 and 26.51 according to criteria A and B, respectively, per 1000 person-years during a median follow-up of 4.8 years. After full adjustment, WCH was associated with an increased risk of renal event (criterion A: hazard ratio 2.36, 95% confidence interval 1.29–4.34; for criterion B: hazard ratio 1.90, 95% confidence interval 1.04–3.49) compared with patients with normal BP.
Conclusions
WCH is associated with a greater risk for renal events in non-dialysis dependent Chinese patients with CKD.
Funder
National Natural Science Foundation of China Beijing Nova Programme Interdisciplinary Cooperation Project the National Key R&D Program of the Ministry of Science and Technology of China the University of Michigan Health System-Peking University Health Science Center Joint Institute for Translational and Clinical Research Peking University the Research Special Fund for Public Welfare Industry of Health from the National Health and Family Planning Commission of the People’s Republic of China the National Key Technology R&D Program of the Ministry of Science and Technology
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
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