Targeting interleukin-6 as a treatment approach for peritoneal carcinomatosis

Author:

Dadgar Neda,Sherry Christopher,Zimmerman Jenna,Park Hyun,Lewis Catherine,Donnenberg Albert,Zaidi Ali H.,Fan Yong,Xiao Kunhong,Bartlett David,Donnenberg Vera,Wagner Patrick L.

Abstract

AbstractPeritoneal carcinomatosis (PC) is a complex manifestation of abdominal cancers, with a poor prognosis and limited treatment options. Recent work identifying high concentrations of the cytokine interleukin-6 (IL-6) and its soluble receptor (sIL-6-Rα) in the peritoneal cavity of patients with PC has highlighted this pathway as an emerging potential therapeutic target. This review article provides a comprehensive overview of the current understanding of the potential role of IL-6 in the development and progression of PC. We discuss mechansims by which the IL-6 pathway may contribute to peritoneal tumor dissemination, mesothelial adhesion and invasion, stromal invasion and proliferation, and immune response modulation. Finally, we review the prospects for targeting the IL-6 pathway in the treatment of PC, focusing on common sites of origin, including ovarian, gastric, pancreatic, colorectal and appendiceal cancer, and mesothelioma.

Funder

A Glimmer of Hope

Publisher

Springer Science and Business Media LLC

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