Author:
Pereira Luanderson Cardoso,Pereira Nathalie de Sena,Barbosa da Silva Andressa Noronha,Bezerra Clarice de Freitas,Sousa Kivia Millana de,Fagundes Neto João Ciro,Sampaio George Harisson Felinto,Brito Carlos Ramon do Nascimento,Souza Rita de Cássia Moreira,Galvão Lúcia Maria da Cunha,Câmara Antônia Claudia Jácome da,Nascimento Manuela Sales Lima,Guedes Paulo Marcos Matta
Abstract
Abstract
Background
Triatoma infestans, Triatoma brasiliensis, Triatoma pseudomaculata and Rhodnius prolixus are vectors of Trypanosoma cruzi, the etiological agent of Chagas disease. Chickens serve as an important blood food source for triatomines. This study aimed to assess the insecticidal activity of fluralaner (Exzolt®) administered to chickens against triatomines (R. prolixus, T. infestans, T. brasiliensis and T. pseudomaculata).
Methods
Twelve non-breed chickens (Gallus gallus domesticus) were randomized based on weight into three groups: negative control (n = 4); a single dose of 0.5 mg/kg fluralaner (Exzolt®) (n = 4); two doses of 0.5 mg/kg fluralaner (Exzolt®) (n = 4). Nymphs of 3rd, 4th and 5th instars of R. prolixus, T. infestans, T. brasiliensis and T. pseudomaculata (all n = 10) were allowed to feed on chickens before treatment, and at intervals of 1, 7, 14, 21, 28, 35 and 56 days after treatment, with insect mortality determined.
Results
Treatment with two doses of fluralaner showed higher insecticidal efficacy against R. prolixus, T. infestans and T. brasiliensis compared to the single-dose treatment. Similar insecticidal efficacy was observed for T. pseudomaculata for one and two doses of fluralaner. Insecticidal activity of fluralaner (Exzolt®) against triatomine bugs was noted up to 21 and 28 days after treatment with one and two doses of fluralaner, respectively.
Conclusions
The results demonstrate that treatment of chickens with fluralaner (Exzolt®) induces insecticidal activity against triatomines for up to 28 days post-treatment, suggesting its potential use as a control strategy for Chagas disease in endemic areas.
Graphical Abstract
Funder
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Publisher
Springer Science and Business Media LLC
Reference66 articles.
1. WHO. Chagas disease (also known as American trypanosomiasis). World Health Organization. 2023. https://www.who.int/health-topics/Chagas-disease#tab=tab_1.
2. Lent H, Wygodzinsky PW. Revision of the Triatominae (Hemiptera, Reduviidae), and their significance as vectors of Chagas’ disease. Bull Am Muse Nat Hist. 1979;163:397.
3. Gourbiere S, Dorn P, Tripet F, Dumonteil E. Genetics and evolution of triatomines: from phylogeny to vector control. Heredity (Edinb). 2012;108:190–202. https://doi.org/10.1038/hdy.2011.71.
4. Noireau F, Diosque P, Jansen AM. Trypanosoma cruzi: adaptation to its vectors and its hosts. Vet Res. 2009;40:26. https://doi.org/10.1051/vetres/2009009.
5. Dias JC, Silveira AC, Schofield CJ. The impact of Chagas disease control in Latin America: a review. Mem Inst Oswaldo Cruz. 2002;97:603–12. https://doi.org/10.1590/s0074-02762002000500002.