Abstract
Abstract
Background
This study investigated the remineralisation effect of bioactive glass on artificial dentine caries.
Methods
Dentine disks with artificial caries were treated with bioactive glass (group BAG), casein phosphopeptide–amorphous calcium phosphate (CPP-ACP) (group CPP-ACP), sodium fluoride glycerol (group F) or deionized water (group W). All disks were subjected to pH cycling for 28 days subsequently. The topography, microhardness and remineralisation depth of the dentine carious lesion were assessed by atomic force microscopy (AFM), microhardness testing and confocal laser scanning microscope (CLSM), respectively.
Results
AFM images indicated mineral depositions on the surface of the carious lesion in group BAG. The changes of Vickers hardness number (ΔVHN, mean ± SD) after pH cycling were 9.67 ± 3.60, 6.06 ± 3.83, 5.00 ± 2.19 and − 1.90 ± 2.09 (p < 0.001) in group BAG, group CPP-ACP, group F and group W, respectively. The remineralisation depth (mean ± SD) of the carious lesion in group BAG, group CPP-ACP, group F and group W were 165 ± 11 μm, 111 ± 11 μm, 75 ± 6 μm and 0 μm (p < 0.001), respectively.
Conclusion
Bioactive glass possessed a promising remineralisation effect on artificial dentine caries and could be a therapeutic choice for caries management.
Publisher
Springer Science and Business Media LLC
Reference35 articles.
1. Rocha Gomes Torres C, Borges AB, Torres LM, Gomes IS, de Oliveira RS. Effect of caries infiltration technique and fluoride therapy on the colour masking of white spot lesions. J Dent. 2011;39(3):202–7.
2. Weir MD, Ruan J, Zhang N, Chow LC, Zhang K, Chang X, Bai Y, Xu HHK. Effect of calcium phosphate nanocomposite on in vitro remineralization of human dentin lesions. Dent Mater. 2017;33(9):1033–44.
3. Innes NPT, Chu CH, Fontana M, Lo ECM, Thomson WM, Uribe S, Heiland M, Jepsen S, Schwendicke F. A century of change towards prevention and minimal intervention in Cariology. J Dent Res. 2019;98(6):611–7.
4. Jones JR. Review of bioactive glass: from Hench to hybrids. Acta Biomater. 2013;9(1):4457–86.
5. Rizwan M, Hamdi M, Basirun WJ. Bioglass® 45S5-based composites for bone tissue engineering and functional applications. Journal of biomedical materials research. Part A. 2017;105(11):3197–223.
Cited by
31 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献