Author:
Hsieh Tsung-Jen,Su Shin-Chang,Chen Chun-Wei,Kang Yaw-Wen,Hu Ming-Hsia,Hsu Li-Lin,Wu Szu-Yun,Chen Likwang,Chang Hsing-Yi,Chuang Shao-Yuan,Pan Wen-Harn,Hsu Chih-Cheng
Abstract
Abstract
Background
Frail older adults are predisposed to multiple comorbidities and adverse events. Recent interventional studies have shown that frailty can be improved and managed. In this study, effective individualized home-based exercise and nutrition interventions were developed for reducing frailty in older adults.
Methods
This study was a four-arm, single-blind, randomized controlled trial conducted between October 2015 and June 2017 at Miaoli General Hospital in Taiwan. Overall, 319 pre-frail or frail older adults were randomly assigned into one of the four study groups (control, exercise, nutrition, and exercise plus nutrition [combination]) and followed up during a 3-month intervention period and 3-month self-maintenance period. Improvement in frailty scores was the primary outcome. Secondary outcomes included improvements in physical performance and mental health. The measurements were performed at baseline, 1 month, 3 months, and 6 months.
Results
At the 6-month measurement, the exercise (difference in frailty score change from baseline: − 0.23; 95% confidence interval [CI]: − 0.41, − 0.05; p = 0.012), nutrition (− 0.28; 95% CI: − 0.46, − 0.11; p = 0.002), and combination (− 0.34; 95% CI: − 0.52, − 0.16; p < 0.001) groups exhibited significantly greater improvements in the frailty scores than the control group. Significant improvements were also observed in several physical performance parameters in the exercise, nutrition, and combination groups, as well as in the 12-Item Short Form Health Survey mental component summary score for the nutrition group.
Conclusions
The designated home-based exercise and nutrition interventions can help pre-frail or frail older adults to improve their frailty score and physical performance.
Trial registration
Retrospectively registered at ClinicalTrials.gov (identifier: NCT03477097); registration date: March 26, 2018.
Funder
Center for Sustainability Science of Academia Sinica
Publisher
Springer Science and Business Media LLC
Subject
Nutrition and Dietetics,Physical Therapy, Sports Therapy and Rehabilitation,Medicine (miscellaneous)
Cited by
77 articles.
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