Abstract
Abstract
Background
Persistent Mullerian Duct Syndrome (PMDS) is a type of pseudo-hermaphroditism occurring in males internally due to failure in the Anti Mullerian Hormone (AMH)-dependent sex differentiation pathway. Due to absent Anti Mullerian Hormone (AMH), the adult male has both the Wolffian and Mullerian duct derivatives. Considering the limited information available in the existing literature, malignant transformation in PMDS has rarely been reported.
Case Presentation
In this article we present two cases of PMDS which have complicated in to malignancy with review of literature and histopathological correlation. Both of these patients presented with lower abdominal pain, for which computed tomography of abdomen and pelvis was performed following ultrasound of abdomen and pelvis Both the Wolffian and Mullerian duct derivates were visualized on the above mentioned scans in these genetically confirmed males (46 XY).
Conclusion
Familiarity with PMDS is necessary to diagnose the condition. Hence, in this article, we report recherche presentations of Persistent Mullerian Duct Syndrome which had complicated into malignancies.
Publisher
Springer Science and Business Media LLC
Subject
Radiology, Nuclear Medicine and imaging
Reference11 articles.
1. Renu D, Rao BG, Ranganath K, Namitha (2010) Persistent Mullerian duct syndrome. Indian J Radiol Imaging 20(1):72–74
2. Agrawal AS, Kataria R (2015) Persistent Müllerian Duct Syndrome (PMDS): a rare anomaly the general surgeon must know about. Indian J Surg 77(3):217–221
3. Alharbi KN, Khushaim AO, Alrasheed M, Akhtar M, Neimatallah M (2017) Radiological findings in persistent Müllerian duct syndrome: case report and review of literature. J Radiol Case Rep 11(3):7–14
4. Picard JY, Cate RL, Racine C, Josso N (2017) The persistent Müllerian duct syndrome: an update based upon a personal experience of 157 cases. Sex Dev 11(3):109–125
5. Wongprasert H, Somanunt S, De Filippo R, Picard JY, Pitukcheewanont P (2013) A novel mutation of anti-Mullerian hormone gene in Persistent Mullerian Duct Syndrome presented with bilateral cryptorchidism: a case report. J Pediatr Urol 9(4):e147–e149
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