Author:
Consoli Angèle,Ronen Karine,An-Gourfinkel Isabelle,Barbeau Martine,Marra Donata,Costedoat-Chalumeau Nathalie,Montefiore Delphine,Maksud Philippe,Bonnot Olivier,Didelot Adrien,Amoura Zahir,Vidailhet Marie,Cohen David
Abstract
Abstract
Anti-NMDA-Receptor encephalitis is a severe form of encephalitis that was recently identified in the context of acute neuropsychiatric presentation. Here, we describe the case of a 17-year-old girl referred for an acute mania with psychotic features and a clinical picture deteriorated to a catatonic state. Positive diagnosis of anti-NMDA-receptor encephalitis suggested specific treatment. She improved after plasma exchange and immunosuppressive therapy. Post-cognitive sequelae (memory impairment) disappeared within 2-year follow-up and intensive cognitive rehabilitation.
Publisher
Springer Science and Business Media LLC
Subject
Psychiatry and Mental health,Pediatrics, Perinatology and Child Health
Reference25 articles.
1. Lau CG, Zukin RS: NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders. Nat Rev Neurosci. 2007, 8 (6): 413-426.
2. Waxman EA, Lynch DR: N-methyl-D-aspartate receptor subtypes: multiple roles in excitotoxicity and neurological disease. Neuroscientist. 2005, 11 (1): 37-49. 10.1177/1073858404269012.
3. Lynch DR, Anegawa NJ, Verdoorn T, Pritchett DB: N-methyl-D-aspartate receptors: different subunit requirements for binding of glutamate antagonists, glycine antagonists, and channel-blocking agents. Mol Pharmacol. 1994, 45 (3): 540-545.
4. Dalmau J, Lancaster E, Martinez-Hernandez E, Rosenfeld MR, Balice-Gordon R: Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis. Lancet Neurol. 2011, 10 (1): 63-74. 10.1016/S1474-4422(10)70253-2.
5. Vitaliani R, Mason W, Ances B, Zwerdling T, Jiang Z, Dalmau J: Paraneoplastic encephalitis, psychiatric symptoms, and hypoventilation in ovarian teratoma. Ann Neurol. 2005, 58 (4): 594-604. 10.1002/ana.20614.
Cited by
55 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献