Abstract
Abstract
Background
Current evidence suggests that the hypoxic tumor microenvironment further aggravates tumor progression, leading to poor therapeutic outcomes. There is as yet no biomarker capable of evaluating the hypoxic state of the tumor. The cytochrome c oxidase (COX) subunit is crucial to the mitochondrial respiratory chain.
Methods
We investigated the potential oncogenic role of COX subunit 4 isoform 2 gene (COX4I2) in colorectal cancer (CRC) by least absolute shrinkage and selection operator (LASSO) and COX regression analysis to examine whether COX4I2 overexpression can predict colorectal cancer (CRC) prognosis. The association of COX4I2 levels with clinical features and its biological actions were evaluated both in vitro and in vivo.
Results
Our analysis showed that elevated COX4I2 levels were correlated with poor clinical outcomes. We also observed that that COX4I2 may be involved in epithelial-mesenchymal transition, activation of cancer-related fibroblasts and angiogenesis in relation to fibroblast growth factor 1.
Conclusions
The COX4I2 level may be a predictor of outcome in CRC and may represent a novel target for treatment development.
Graphical Abstract
Funder
Youth Science and Technology Project of Suzhou
Key Laboratory in Science and Technology Development Project of Suzhou
Science and Technology Support Plan for Youth Innovation of Colleges and Universities of Shandong Province of China
Peak Academic Talent Project of Jiangsu Provincial Hospital of Traditional Chinese Medicine
Advantageous Disciplines Program of Nanjing University of Chinese Medicine
Science and Technology Project of Affiliated Hospital of Nanjing University of Chinese Medicine
Zhejiang Traditional Chinese Medicine Administration
Three-Side Innovation Projects for Aquaculture in Jiangsu Province
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology,Biochemistry
Cited by
11 articles.
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