Jaboticaba (Plinia jaboticaba (Vell.) Berg) polyphenols alleviate skeletal muscle insulin resistance by modulating PI3K/Akt/GLUT-4 and AMPK signaling pathways in diet-induced obese mice-Reference-Cited by-同舟云学术

Jaboticaba (Plinia jaboticaba (Vell.) Berg) polyphenols alleviate skeletal muscle insulin resistance by modulating PI3K/Akt/GLUT-4 and AMPK signaling pathways in diet-induced obese mice

Published:2024-08-04 Issue:1 Volume:6 Page:
ISSN:2661-8974
Container-title:Food Production, Processing and Nutrition
language:en
Short-container-title:Food Prod Process and Nutr

Author:

Pessoa Érika V. M.,Moura Márcio H. C.,Rodrigues Larissa,Rossi e Silva Rafaela,Castro Érique,Festuccia William T.,Donado-Pestana Carlos M.^ORCID,Genovese Maria Inés

Abstract

AbstractSkeletal muscle responds for most of the insulin-stimulated glucose disposal at postprandial state, impacting glucose homeostasis. Polyphenols were shown to prevent obesity-associated glucose intolerance and peripheral insulin resistance in animal models, but the implication of skeletal muscle to these effects is unclear. We investigated the role of polyphenolic extracts from jaboticaba (Plinia jaboticaba (Vell.) Berg) (PEJ), a Brazilian native species, on skeletal muscle insulin resistance in diet-induced obese mice. PEJ administration was associated with an increase in skeletal muscle protein content of glucose transporter-4 (GLUT-4) and AMP-activated protein kinase (AMPK) phosphorylated at Thr172. PEJ also reduced skeletal muscle mRNA levels of inflammatory genes nuclear factor-ҡB (NF-κB), tumoral necrose factor-α (TNF-α), interleukin 1β (IL-1β), and c-Jun N-terminal kinase (JNK). This study demonstrates that polyphenols from jaboticaba may be a valuable therapeutic agent in the management and prevention of obesity-associated metabolic disorders by reducing skeletal muscle obesity-associated insulin resistance and inflammation. Graphical Abstract

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

Springer Science and Business Media LLC

Link

https://link.springer.com/content/pdf/10.1186/s43014-024-00230-y.pdf

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