Author:
Sartelli Massimo,Barie Philip,Agnoletti Vanni,Al-Hasan Majdi N.,Ansaloni Luca,Biffl Walter,Buonomo Luis,Blot Stijn,Cheadle William G.,Coimbra Raul,De Simone Belinda,Duane Therese M.,Fugazzola Paola,Giamarellou Helen,Hardcastle Timothy C.,Hecker Andreas,Inaba Kenji,Kirkpatrick Andrew W.,Labricciosa Francesco M.,Leone Marc,Martin-Loeches Ignacio,Maier Ronald V.,Marwah Sanjay,Maves Ryan C.,Mingoli Andrea,Montravers Philippe,Ordóñez Carlos A.,Palmieri Miriam,Podda Mauro,Rello Jordi,Sawyer Robert G.,Sganga Gabriele,Tattevin Pierre,Thapaliya Dipendra,Tessier Jeffrey,Tolonen Matti,Ulrych Jan,Vallicelli Carlo,Watkins Richard R.,Catena Fausto,Coccolini Federico
Abstract
AbstractIntra-abdominal infections (IAIs) are an important cause of morbidity and mortality in hospital settings worldwide. The cornerstones of IAI management include rapid, accurate diagnostics; timely, adequate source control; appropriate, short-duration antimicrobial therapy administered according to the principles of pharmacokinetics/pharmacodynamics and antimicrobial stewardship; and hemodynamic and organ functional support with intravenous fluid and adjunctive vasopressor agents for critical illness (sepsis/organ dysfunction or septic shock after correction of hypovolemia). In patients with IAIs, a personalized approach is crucial to optimize outcomes and should be based on multiple aspects that require careful clinical assessment. The anatomic extent of infection, the presumed pathogens involved and risk factors for antimicrobial resistance, the origin and extent of the infection, the patient’s clinical condition, and the host’s immune status should be assessed continuously to optimize the management of patients with complicated IAIs.
Publisher
Springer Science and Business Media LLC