Author:
Weng Xinyu,Zheng Min,Liu Yanning,Lou Guohua
Abstract
AbstractBach2 was initially discovered in B cells, where it was revealed to control the transcription involved in cell differentiation. Bach2 is intimately connected to CD8 + T lymphocytes in various differentiation states and subsets according to recent findings. Bach2 can regulate primitive T cells, stimulate the development and differentiation of memory CD8 + T cells, inhibit the differentiation of effector CD8 + T cells, and play a significant role in the exhaustion of CD8 + T cells. The appearance and development of diseases are tightly linked to irregular CD8 + T cell differentiation and function. Accordingly, Bach2 offers novel approaches and possible targets for the clinical treatment of associated disorders based on research on these pathways. Here, we summarize the role of Bach2 in the function and differentiation of CD8 + T cells and its potential clinical applications.
Funder
National Natural Science Foundation of China
Independent Task of State Key Laboratory for Diagnosis and Treatment of Infectious Diseases
Publisher
Springer Science and Business Media LLC
Reference36 articles.
1. Kuwahara M, Suzuki J, Tofukuji S, Yamada T, Kanoh M, Matsumoto A, et al. The Menin-Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis. Nat Commun. 2014;5:3555.
2. Patry RT, Nagler CR. Fiber-poor western diets fuel inflammation. Nat Immunol. 2021;22:266–8.
3. Reina-Campos M, Scharping NE, Goldrath AW. CD8 + T cell metabolism in infection and cancer. Nat Rev Immunol. 2021;21:718–38.
4. Igarashi K, Ochiai K, Itoh-Nakadai A, Muto A. Orchestration of plasma cell differentiation by Bach2 and its gene regulatory network. Immunol Rev. 2014;261:116–25.
5. Yang L, Chen S, Zhao Q, Sun Y, Nie H. The critical role of Bach2 in shaping the balance between CD4 + T cell subsets in Immune-mediated diseases. Mediators Inflamm. 2019;2019:1–9.