Early nonreactivity in the conjunctival provocation test predicts beneficial outcome of sublingual immunotherapy

Author:

Köther Janina,Mandl Alicia,Allekotte Silke,Astvatsatourov Anatoli,Chwieralski Janin,Liedtke Jan-Patrick,Pieper-Fürst Ursula,Raskopf Esther,Shah-Hosseini Kija,Mösges Ralph

Funder

Lofarma, S.p.A., Milan, Italy

Publisher

Wiley

Subject

Immunology and Allergy,Immunology,Pulmonary and Respiratory Medicine

Reference32 articles.

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2. Khinchi MS, Poulsen LK, Carat F, André C, Hansen AB, Malling HJ. Clinical efficacy of sublingual and subcutaneous birch pollen allergen-specific immunotherapy: a randomized, placebo-controlled, double-blind, double-dummy study. Allergy. 2004;59(1):45–53. https://doi.org/10.1046/j.1398-9995.2003.00387.x .

3. Ott H, Sieber J, Brehler R, Fölster-Holst R, Kapp A, Klimek L, et al. Efficacy of grass pollen sublingual immunotherapy for three consecutive seasons and after cessation of treatment: the ECRIT study. Allergy. 2009;64(1):179–86. Erratum in Allergy. 2009;64(9):1394–401. https://doi.org/10.1111/j.1398-9995.2009.02194.x .

4. Pfaar O, van Twuijver E, Boot JD, Opstelten DJ, Klimek L, van Ree R, et al. A randomized DBPC trial to determine the optimal effective and safe dose of a SLIT-birch pollen extract for the treatment of allergic rhinitis: results of a phase II study. Allergy. 2016;71(1):99–107. https://doi.org/10.1111/all.12760 .

5. Durham SR, Emminger W, Kapp A, de Monchy JG, Rak S, Scadding GK, et al. SQ-standardized sublingual grass immunotherapy: confirmation of disease modification 2 years after 3 years of treatment in a randomized trial. J Allergy Clin Immunol. 2012;129(3):717–25. https://doi.org/10.1016/j.jaci.2011.12.973 .

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