The effect of dihydropyrazines on human hepatoma HepG2 cells: a comparative study using 2,3-dihydro-5,6-dimethylpyrazine and 3-hydro-2,2,5,6-tetramethylpyrazine
Author:
Affiliation:
1. Faculty of Pharmaceutical Sciences, Sojo University
Publisher
Japanese Society of Toxicology
Subject
Toxicology
Link
https://www.jstage.jst.go.jp/article/jts/39/4/39_601/_pdf
Reference16 articles.
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3. Ishii, T., Itoh, K. and Yamamoto, M. (2002): Roles of Nrf2 in activation of antioxidant enzyme genes via antioxidant responsive elements. Methods Enzymol., 348, 182-190.
4. Ishida, T., Takechi, S. and Yamaguchi, T. (2012): Possible involvement of glutathione balance disruption in dihydropyrazine-induced cytotoxicity on human hepatoma HepG2 cells. J. Toxicol. Sci., 37, 1065-1069.
5. Kashige, N., Yamaguchi, T., Miake, F. and Watanabe, K. (2000): Nucleotide sequence specificity in DNA cleavage caused by dihydropyrazines, a new type of DNA strand-cleaving agent. Biol. Pharm. Bull., 23, 1281-1286.
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