Association between in vitro nuclear receptor-activating profiles of chemical compounds and their in vivo hepatotoxicity in rats

Author:

Kodama Susumu1,Yoshii Nao1,Ota Akihiro1,Takeshita Jun-ichi2,Yoshinari Kouichi3,Ono Atsushi1

Affiliation:

1. Laboratory of Toxicology, Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University

2. Reserach Institute of Science for Safety and Sustainability, National Institute of Advanced Industrial Science and Technology (AIST)

3. Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka

Publisher

Japanese Society of Toxicology

Subject

Toxicology

Reference54 articles.

1. Abe, T., Takahashi, M., Kano, M., Amaike, Y., Ishii, C., Maeda, K., Kudoh, Y., Morishita, T., Hosaka, T., Sasaki, T., Kodama, S., Matsuzawa, A., Kojima, H. and Yoshinari, K. (2017): Activation of nuclear receptor CAR by an environmental pollutant perfluorooctanoic acid. Arch. Toxicol., 91, 2365-2374.

2. Ankley, G.T., Bennett, R.S., Erickson, R.J., Hoff, D.J., Hornung, M.W., Johnson, R.D., Mount, D.R., Nichols, J.W., Russom, C.L., Schmieder, P.K., Serrrano, J.A., Tietge, J.E. and Villeneuve, D.L. (2010): Adverse outcome pathways: a conceptual framework to support ecotoxicology research and risk assessment. Environ. Toxicol. Chem., 29, 730-741.

3. Boergesen, M., Pedersen, T.A., Gross, B., van Heeringen, S.J., Hagenbeek, D., Bindesbøll, C., Caron, S., Lalloyer, F., Steffensen, K.R., Nebb, H.I., Gustafsson, J.A., Stunnenberg, H.G., Staels, B. and Mandrup, S. (2012): Genome-wide profiling of liver X receptor, retinoid X receptor, and peroxisome proliferator-activated receptor α in mouse liver reveals extensive sharing of binding sites. Mol. Cell. Biol., 32, 852-867.

4. Commerford, S.R., Vargas, L., Dorfman, S.E., Mitro, N., Rocheford, E.C., Mak, P.A., Li, X., Kennedy, P., Mullarkey, T.L. and Saez, E. (2007): Dissection of the insulin-sensitizing effect of liver X receptor ligands. Mol. Endocrinol., 21, 3002-3012.

5. Corton, J.C., Peters, J.M. and Klaunig, J.E. (2018): The PPARα-dependent rodent liver tumor response is not relevant to humans: addressing misconceptions. Arch. Toxicol., 92, 83-119.

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